Translational Research Cancer Centers Consortium
2016 Annual Meeting

Planning Committee 

CHAIRS   
  Connie Rogers, Ph.D.
Assistant Professor and Occupant of the Broadhurst Career Development Professorship for the Study of Health Promotion and Disease Prevention
College of Health and Human Development
Nutritional Sciences
PennState Hershey Cancer Institute
  Todd Schell, Ph.D
Associate Professor
College of Medicine
Microbiology and Immunology
PennState Hershey Cancer Institute 

2016 TRCCC Annual Meeting 


FEBRUARY 17-19, 2016
SEVEN SPRINGS, PA

MEETING CHAIRS: 
Connie Rogers,Ph.D
Todd Schell, Ph. D 


ORGANIZING CENTER: 



   

  
     

Keynote Speakers

  IMMUNE CHECKPOINT BLOCKADE – FROM THERE TO HERE
Charles Drake, M.D., Ph.D.
Co-Director Prostate Cancer Multi-Disciplinary Clinic
Professor of Oncology
Professor of Urology
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center 
  Mechanisms of Graft-vs-Leukemia and Graft-vs-Leukemia Resistance
Warren Shlomchik, M.D.
Professor of Medicine
Director, Hematopoietic Stem Cell Transplantation and Cell Therapies
Scientific Director, Hematopoietic Malignancies
University of Pittsburgh Cancer Institute


AGENDA
Please note: the meeting agenda is subject to change.

Wednesday, February 17

2-6 pm
Registration and Poster Set-Up
2:45 pm
Welcome Address
Raymond J. Hohl, M.D., Ph.D.
Professor, Departments of Medicine and Pharmacology
Director, Penn State Cancer Institute 

3 pm
Introduction of Keynote Speaker 
Moderator: Dr. Dario Vignali

Opening Keynote Lecture - Profiling Tumor Infiltrating Lymphocytes with RNAseq
Charles G. Drake, MD, PhD 
Professor of Oncology and Urology
Co-director, Prostate Cancer Multi-Disciplinary Clinic
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

4 pm
Break
4:15-6:30 pm   Symposium 1 : Targeting Immune Suppression in Cancer
(20 minute presentations, 5 minutes for questions)


Chemotherapy-Induced Biology of PD-L1 and In Vivo Combination Immune Therapy for Ovarian Cancer
Anda Vlad, M.D., Ph.D., Pittsburgh Cancer Institute

Chimeric Antigen Receptors for Hematological Malignancies: Beyond CART19
Marco Ruella, M.D., University of Pennsylvania

T Cell Exhaustion in AML Patients
Hong Zheng, M.D., Ph.D., Penn State Cancer Institute

Enhancing Myeloid Cell Effector Functions in Monoclonal Antibody Therapy
Susheela Tridandapani, Ph.D., Ohio State University

Joseph Barbi, PhD, Roswell Park Cancer Institute
6:40-9 pm

Welcome Reception
Meet with delegates, browse posters and sponsor exhibits. Stage 1 of sponsor scavenger hunt

Discussion of Multi-institutional Trials (7:30-8:15)


Thursday, February 18

7 am
Breakfast
8 am  Registration 
8:30 am
Concurrent Trainee Sessions 1 & 2

Session 1: Tumor Microenvironment #1 
      Chairs: Drs. Wei-Zen Wei and Minkyung Song

Session 2: Cell Therapies 
      Chairs: Drs. John Frelinger and David Klinke
  • 10 trainees in each session
  • 5 minutes presentation, 2 minutes questions
9:45 am Browse Posters and Sponsor Exhibits 
10 - 11:45 pm Symposium 2: Cancer Therapeutics
Moderators: Drs. Maria Castro and Jonathan Bramson
20 minutes presentation, 5 minutes questions

Triple Combination Therapy to Enhance the Immunogenicity of HSV-1 Oncolytic Virus Vectors
Karen Mossman, Ph.D., McMaster University

Making a T Time for Herpes Cancer Virotherapy
Timothy Cripe, M.D., Ph.D., Ohio State University

Selective Targeting of Leukemia Stem Cells by Bioactive Lipid Mediators
Robert Paulson, Ph.D, Penn State University

*Short talk*
  Selected from abstracts

11:50 am - 12:15 pm  Platinum Sponsor Presentation - Affymetrix/eBioscience

Leveraging Novel Single-Cell Analysis Techniques in Studying the  Tumor  
Microenvironment

Basile Siewe, PhD  - Application Specialist / Affymetrix

12:30 pm
Advocate Networking Lunch
Patient advocates will be available for one-on-one discussions with delegates.

12:45 -  Introduction of patient advocates and discussion - Ruth Modzelewski, PhD
1:30 pm Concurrent Trainee Sessions 3 & 4

Session 3: Translational and Clinical Cancer Studies 
                 Chairs: Drs. Marc Ernstoff and Robert Vonderheide

Session 4: Tumor Microenvironment #2
                 Chairs: Drs. Joseph Barr and Micheal Lotze
  • 10 trainees in each session
  • 5 minutes presentation, 5 minutes questions
2:45 pm
Break
3 pm 
Symposium 3: Targeting Metabolism in Cancer
Moderators: Drs. Greg Lesinski and Connie Rogers
(20 minute presentations, 5 minutes for questions)

Rab Geranylgeranylation Is a Novel Target in Multiple Myeloma
Sarah Holstein, M.D., Ph.D., Roswell Park Cancer Institute

Targeting CD44-ERO1L-IP3R-SOCE Mediated Regulation of Calcium Homeostasis for the Treatment of Multiple Myeloma
Lori Hazlehurst, PhD, West Virginia University

Molecular Imaging of Tryptophan Metabolism and the Kynurenine Pathway
Csaba Juhasz, M.D., Ph.D., Karmanos Cancer Institute

*Short Talk* 
Selected from abstracts
5:20 pm  Platinum Sponsor Presentation - Biolegend

Time to GoInVivoTM : Validated Checkpoint Antibodies for Cancer Research
Miguel A. Tam, Senior Product Manager, Biolegend
6 pm  Networking session
Browse posters and sponsor exhibits
Final stage of sponsor scavenger hunt
6:15-8:30 pm Dinner and Formal Poster Presentations



Friday, February 19

7 am
Breakfast 
8:15 am
Concurrent Trainee Sessions 5 & 6

Session 5: Viral therapies/ Vaccines
Chairs: Drs. Balveen Kaur and Todd Schell

Session 6: Emerging Therapies 
Chairs: Drs. Lawrence Lum and Elizabeth Repasky 
  • 10 trainees in each session
  • 5 minutes presentation, 5 minutes questions
9:45 am

Break & Hotel Check Out
10:15 am

Meet the Patient 
Joseph Drabick, M.D., FACP, Penn State Hershey Cancer Institute

Patients receiving immunotherapy will discuss the therapy and outcomes along with their attending physicians and the audience.

The session will provide an opportunity for the TRC3 membership to discuss the impact of these therapies with patient advocates and physicians.
11 am
Symposium 4: Cancer Immunotherapeutics
Moderators: Drs. Yasmin Thanavala and Pawel Kalinski
20 minutes presentation, 5 minutes questions

Therapuetic Potential of CCR2 Inhibition in Cancer
Scott Gerber, Ph.D,, University of Rochester

IL-17 signaling in tumorigenesis
Xiaoxia Li, Cleveland Clinic Lerner Research Institute

Engineered nanoparticles for personalized cancer vaccines
James Moon, Ph.D., University of Michigan

12:30 pm
Lunch
1:30 pm
Closing Keynote Lecture - Mechanisms of Graft-vs-Leukemia and Graft-vs-Leukemia Resistance
Warren Shlomchik, M.D.
Professor of Medicine
Director, Hematopoietic Stem Cell Transplantation and Cell Therapies
Scientific Director, Hematopoietic Malignancies
University of Pittsburgh Cancer Institute
2:30 p.m.  Trainee Award Ceremony 
Yasmin Thanavala, Ph.D.
 
2:30 pm
Closing Remarks and Meeting Adjournment
Todd Schell, PhD and Connie Rogers, PhD – Penn State Cancer Institute 

Sponsors

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