Translational Research Cancer Centers Consortium
2015 Annual Meeting

Planning Committee 

  Chair
Jonathan Bramson, PhD
Professor
Pathology and Molecular Medicine
McMaster University
Committee Members  

Ali Ashkar, Professor, Ph.D
Department of Pathology and Molecular Medicine
McMaster University

Brian Lichty, Ph.D
Associate Professor, Department of Pathology and Molecular Medicine
McMaster University 

Karen Mossman, Ph.D.
Chair, Department of Biochemistry and Biomedical Sciences
McMaster University 

Carl Richards, Ph.D.
Director, McMaster Immunology Research Center
McMaster University 

Yonghong Wan, Ph.D.
Professor, Department of Pathology and Molecular Medicine
McMaster University 

Participating Organizations

McMaster University
University of Pennsylvania, Abramson Cancer Center
Barbara Ann Karmanos Cancer Institute
Case Western Reserve University, Case Comprehensive Cancer Center
Mary Babb Randolph Cancer Center at West Virginia University 
University of Michigan Comprehensive Cancer Center
The James, The Ohio State University Comprehensive Cancer Center
Penn State Hershey Cancer Institute 
University of Rochester
Roswell Park Cancer Institute
University of Pittsburgh Medical Center Cancer Center

2015 TRCCC Annual Meeting 


FEBRUARY 18-20, 2015
SEVEN SPRINGS, PA

MEETING CHAIR: 
Jonathan Bramson, PhD.

ORGANIZING CENTER: 



     

KEYNOTE PRESENTATIONS

Updates on Engineered T Cells for Cancer Therapy

Dr. Carl June
Richard W. Vague Professor in Immunotherapy, Department of Pathology and Laboratory Medicine, University of Pennsylvania
Targeting Tregs in Tumors

Dr. Dario Vignali
Vice-Chair, Department of Immunology, University of Pittsburgh


AGENDA
Please note: the meeting agenda is subject to change.

Wednesday, February 18, 2015

2 pm
Registration and Poster Set-Up
3 pm
Welcome Address
Jonathan Bramson
3:15 pm
Opening Keynote Lecture - Targeting Tregs in Tumors
Dr. Dario Vignali, University of Pittsburgh
Introduction by Chair Brian Lichty 
4:15 pm
Break
4:30 pm   Platinum sponsor seminar - eBiosciences 
5 - 6:40 pm Symposium 1 - Translational Studies
Chairs: Kelvin Lee & Soumit Basu
20 minutes presentation, 5 minutes questions

Blockade of Inflammatory Monocytes in Pancreas Cancer: Results of a Phase Ib/II Trial in Borderline Resectable & Locally Advanced Disease
David Linehan, University of Rochester

Prospect of chimeric antigen receptor T cell therapy for acute myeloid leukemia
Saar Gill, University of Pennsylvania


From an evolutionary theory of the brain immune system, to a Phase I Clinical Trial for Glioblastoma Multiforme
Pedro Lowenstein

Engineering Lymph node Targeting Cancer Vaccines through 'Albumin-hitchhiking’
Haipeng Liu, Karamanos

6:40 - 9 pm
Opening Night Mixer – meet with delegates, browse posters and sponsor exhibits


Thursday, February 19, 2015

7 am
Breakfast
8:30 am
Concurrent Trainee Sessions 1 & 2
Session 1 Chairs : Gregory Lesinski & Robert Vonderheid
Session 2 Chairs : Betsy Repasky & Weiping Zhou
  • 10 trainees in each session
  • 5 minutes presentation, 5 minutes questions
9:45 am Browse Posters and Sponsor Exhibits 
10:15 am - 12 pm Symposium 2: Cell Therapies
Chairs: Pawel Kalinski & Balveen Kaur
20 minutes presentation, 5 minutes questions

Intratumoral Determinants of Effective Adoptive Cell Therapy
Marcela Diaz, Case Western

Innovative Approaches to Universal Cancer Immunotherapy
Dan Powell, U. Pennsylvania

Natural Killer Cell Biology and Its Application for Cancer Treatment
Jianhua Yu, Ohio State

Versatile Approaches to Boost T Cell Therapies for Cancer
Richard Koya, Roswell Park

12 pm
Advocate Networking Lunch
Patient advocates will be available for one-on-one discussions with delegates
1:30 pm Concurrent Trainee Sessions 3 & 4
Session 3 Chairs : Joe Baar & Michael Lotze
Session 4 Chairs : Wei-Zen Wei & Todd Schell
  • 10 trainees in each session
  • 5 minutes presentation, 5 minutes questions
2:45 pm
Break
3 pm  Platinum sponsor seminar – Alexion Pharmaceuticals
Dr. Elizabeth Griffiths, Roswell Park

3:30 pm  Break 
3:45 pm 
Symposium 3: Tumor Immunity
Chairs: Yonghong Wan & John Frelinger
20 minutes presentation, 5 minutes questions

Conditioning Tumor Microenvironment for Immune Attack: Adhesion Molecules and Immune Checkpoint Modulation
Alex Huang, Case Western

CXCL12/CXCR4 Blockade by Oncolytic Virotherapy Inhibits Cancer Metastases by Targeting Tumor Microenvironment and Cancer Initiating Cells
Danuta Kobzor, Roswell Park

Preclinical efficacy of PD-L1 blockade in a human MUC1-expressing ovarian cancer mouse model
Anda Vlad, University of Pittsburgh

Oncogenic Kras and the myeloid cells' contribution to pancreatic cancer
Marina Pasca Di Magliano, U. Michigan

5:30 pm  Break 
6 pm Dinner and Poster Presentations



Friday, February 21, 2014

7 am
Breakfast 
8:30 am
Concurrent Trainee Sessions 5 & 6
Session 5 Chairs : Maria Castro 
Session 6 Chairs : Gregory Plautz & Scott Abrams
  • 10 trainees in each session
  • 5 minutes presentation, 5 minutes questions
9:45 am

Break
10:15 am

Meet the Patient 
Ahmad Tarhini, UPCI

Patients receiving immunotherapy will discuss the therapy and outcomes along with their attending physicians.
11 am
Symposium 4: Tumor microenvironment
Chairs: Drs. David Linehan & Dan Powell
20 minutes presentation, 5 minutes questions

Skewing inflammation and mouse models of cancer growth in lung
Carl Richards, McMaster

Danger signal IL33 and antitumor Immunity 
Binfeng Lu, U. Pittsburgh

Distinct Tumor Immune Responses Are Dependent on Location of Oncogene Expression Within Differentiation Hierarchy of Stratified Epithelium
Adam Glick, Penn State

12:30 pm
Lunch
1:30 pm
Closing Keynote Lecture - Updates on Engineered T Cells for Cancer Therapy
Carl June, University of Pennsylvania
Introduction by Chair Dr. Karen Mossman
2:30 pm
Meeting Adjournment
Closing remarks & presentation of trainee awards

Trainee Awards supported by AAI



 
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